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Cancer prostata tnm. Stadializarea TNM: principii și rolul acesteia în oncologie

Vincenz-Hospital, Limburg, Germany The sentinel node concept SNC and the sentinel node procedure SNP is crucial to understand the relationship of the primary tumor to its re­gional lymphatics.

The adjuvant radiotherapy to lymphatic basins indicated by the SNP could avoid a systematic lymphadenectomy in sentinel node positive patients. We will present here the concept of sentinel node navigation radiotherapy.

Also we shall present data on the selection of lympatic areas to be included in the clinical target volume CTV in head and neck, breast, apparently localized prostate cancer and Merkell Cell carcinoma patients based prostate cancer staging tnm the pattern of lymphatic spread indicated by the SNP.

Conformal irradiation techniques for adjuvant radio­therapy of the head and neck, axillary and internal mammary chain IMCinguinal and pelvic lymphatic areas are presented. Basic data on the lymphatic drainage and involvement of different lymph nodes for head and neck, breast, and prostate cancer as well as Merkel Cell carcinoma patients based on the SNP were used.

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  4. Magnetic Resonance Imaging MRI is the best imaging modality for evaluating the prostate and accurately diagnose the prostatic carcinoma, especially in cases with aggressive and larger volume tumors.
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  7. Prostate cancer TNM staging Cancer prostata tnm LinkedIn Stadializarea TNM: principii și rolul cancer prostata tnm în oncologie Cancerul este o boală mondială, componentă foarte importantă a patologiei umane şi una din cauzele majore de deces după bolile cardio — vasculare.

For treatment planning and CTV delineation the individual location of lymph nodes in axial CT slices was used. The data obtained using the SNP changed the criteria of selection prostate cancer staging tnm different lymphatic basins to be included in the CTV in a sig­nificant manner. In Merkel Cell carcinoma pa­tients the SNP is the only available method to describe the individual lymphatic basin and to adapt the optimal treatment strategy.

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The conven­tional irradiation techniques for lymphatic areas in the axilla, IMC, groin and pelvis actually in use are not adequate and have side effects. At our institution new conformal irradiation techniques for lymphatic areas or basins have been developed and are presented here.

The concept of the sentinel node navigation radiotherapy and the individual selection of lymphatic areas to be included in the CTV based on the SNP were presented.

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Sparing of organs at risk and homogenous dose coverage of the CTV using the proposed irradiation techniques is possible. Methods: The crude, age-specific and directly age-standardized incidence and mortality rates for GU cancers in Romania were calculated.

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Time trend of the incidence and mortality was assessed by the percent change between and Results: Although in Romania, incidence and mortality rates of GU cancers are lower than in western countries, there was a general increase in the incidence and mortality during the registered period. For urological cancers, the increase concerned both sexes, though incidence and mortality rates in women remained significantly lower than in men.

Conclusions: Our data support that the application of available knowledge on prevention, diagnosis and treatment of these cancers could define a strat­egy to reduce during the following years the impact of the ascending course of incidence and mortality through GU cancers in Ro­mania.

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Results: 32 patients received prior adjuvant treatment 5FU based in both groups, 7 stage II at diagnosis and 25 stage III at diagnosis; 41 patients from both groups received no prior chemotherapy stage IV disease before enrollment. Both regimens proved to be active; 4 Except for one death by myocardial infarction possibly related to Capecitabine therapy, toxicity was mild, with very few grade three events.

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Median follow-up was 12 months, range Median overall survival was Conclusion: Both regimens proved active in metastatic setting, with moderate tox­icity and increased compliance from patients. Surgery was planned weeks after the completion of radiochemotherapy.

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The pathological specimen was evaluated for primary tumor, number of examined lymph nodes and resection margins. The compliance and toxicity of the concomitant preoperative treatment, and complications after surgery were recorded.

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The pathological response rate pCR was complete in The grade 3 toxicity was mainly hematological No grade 4 toxicity was registered. Conclusions: Concomitent preoperative radiochemotherapy with Capecitabine in patients with locally advanced rectal adenocarcinoma has a strong rational support: efficacy, favorable safety profile and moderate toxicity.

The oral chemotherapy i. Key words: Colorectal Cancer, Adjuvant Treatment.

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Bisphospho­nates BP represent an important method of their treatment. Purpose: to evaluate the efficiency and toxicity of different type of BP in terms of the incidence of skeletal events, the time to the first skeletal- related event and the incidence and severity of adverse ef­fects. The median age of the patients was 66 years.

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At least three cycles of BP were administered, half of them being with zoledronic acid. The median time until the first event was 17 months 22 for Zometa vs.

None of the patients underwent bone surgery. Se­vere toxicity resulted in osteonecrosis of the mandible 1case and kidney failure 1 case. The other adverse effects included arthral­gia, myalgia, temporary exacerbation of bone pain and gastrointestinal adverse reactions.

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Conclusions: Zoledronic acid seems to be more effective in treating bone metastases since it reduces the incidence of skeletal events and increases the time interval until the first skeletal related event, compared to Aredia or Clodronate. Key words: Bisphosphonates, Prostate Cancer.

Its diagnosis is difficult and very often late be­cause the lesion originates in the submucosa of the stomach wall endoscope biopsy is often inconclusive and also because of the unspecific clinical manifestations prostate cancer staging tnm with distant metastasis absence of carcinoid syndrome. The proper therapeutic attitude in­cludes removal of the tumour surgically or endoscopically along with complementary chemotherapy, depending on the carcinoid type, size of the lesion and disease stage.

We hereby give our personal experience with regard to the problems of diagnostic and clas­sification by the type of patients diagnosed with gastric malignant carcinoids in our survey.

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This paper also presents particularities of surgical and complementary treatment and of the postoperative outcome. Small molecule tyrosine kinase inhibitors may change the outlook in these patients.

We present the case of a 62 year old female who was diagnosed in March with chronic phase, Philadelphia positive CML. She was initially treated with hydroxyurea with the achievement of a complete haematological response CHR but in July the patient progressed to blastic phase. Subsequently, the patient was started on dasatinib 2 x 70mg daily gaining the achievement of CHR after one month. Major cytogenetically remission was obtained in 3 months prostatita omega 3 complete cytogenetically remission CCR in 6 months.

This case report underscores the progress being made in recent years in the treatment of CML, even in advanced phases, due to the introduction of tyrosine kinase inhibitors.